Calorie Restriction focus: cell signaling not weight loss

The CR Way to Happy Dieting offers delicious recipes.

Whether you call it calorie restriction ( CR), caloric restriction, or CRON(Calorie Restriction Optimal Nutrition), The CR Way approach to caloric restriction avoids adverse effects, seen in so many low-calorie diets. Although losing weight is easy when practicing calorie restriction, the CR Way is not primarily about weight loss and is never about excessive weight loss. In fact, it is above all about changing cell signaling – how your cells talk to each other. And while some people use the CR Way to lose weight healthfully, some others who begin the lifestyle should not lose one pound. They focus more on optimal health, which begins in your cells.

The CR Way to calorie restriction supercharges cells

Cells in many body tissues are constantly replicating – an essential part of your biology. To power the replication process, cells need energy – which you provide them in the form of calories from the food you eat. If you deny cells energy through intelligent calorie restriction, they adapt very beneficially. Your energy-regulating system, coordinated by hormones and many other energy-sensitive cellular signals, shifts gears from energy usage to energy production. Ancient genes – like the sirtuins1, which evolved when the early organisms had to go without food – become active and supercharge your cells for survival so they can make it through the calorie-restricted period.  Cells begin to use energy more efficiently, and energy production revs up. Meanwhile, anabolic drivers (substances that drive tissue growth), like mTOR – an enzyme associated with cancer and accelerated aging, become quiescent2. If the calorie restriction period is extended, fat in food as well as your body’s stored fat, is burned for energy needs. This is why losing weight is easy with a CR Way diet.

Often when people hear the words calorie restriction, they get scared – sometimes recalling tabloid stories, distorting what the lifestyle is really about. That is why many who seek optimal health are pleasantly surprised to learn how easy the CR Way approach to calorie restriction really is.  In fact, The CR Way can begin without limiting a single calorie!

New practitioners use The CR Way® to Happy Dieting, a down-loadable resource that shows how to plan food choices and other parts of your lifestyle to increase happiness. This innovative approach makes it easy not to return to unhealthful comfort foods that keep lots of people from successful dieting. This approach frees dieters – making it easier to enjoy healthful, delicious food that allows them to turn calorie restriction into liberation from the idea the high-calorie foods make you happy – when, in fact, they will eventually kill you.

You can find out more from this University of California, San Francisco, video . Here, we introduce The CR Way® to Happy Dieting,  which is a benefit of Healthful Weight Loss Members of

Tools like The CR Way® to Happy Dieting are combined with live teleconferences so people can learn how to capitalize on calorie restriction’s positive effects while avoiding adverse effects that often stem from misinformation or even disinformation.

1 Sirtuins: the ‘magnificent seven’, function, metabolism and longevity.

Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J.

Annals of Medicine. 2007;39(5):335-45.

The sirtuin family of histone deacetylases (HDACs) was named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has been shown to mediate the effects of calorie restriction on the extension of life span and high levels of Sir2 activity promote longevity. Like their yeast homologs, the mammalian sirtuins (SIRT1-7) are class III HDACs and require NAD(+) as a cofactor to deacetylate substrates ranging from histones to transcriptional regulators. Through this activity, sirtuins are shown to regulate important biological processes ranging from apoptosis, adipocyte and muscle differentiation, and energy expenditure to gluconeogenesis. We review here the current knowledge regarding the role of sirtuins in metabolism, longevity, and discuss the possible therapeutic applications that could result from the understanding of their function in different organs and pathologies.

PMID: 17701476

2 Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

Blagosklonny MV.

Cell Cycle. 2010 Feb 15;9(4):683-8.

Although it has been known since 1917 that calorie restriction (CR) decelerates aging, the topic remains highly controversial. What might be the reason? Here I discuss that the anti-aging effect of CR rules out accumulation of DNA damage and failure of maintenance as a cause of aging. Instead, it suggests that aging is driven in part by the nutrient-sensing TOR (target of rapamycin) network. CR deactivates the TOR pathway, thus slowing aging and delaying diseases of aging. Humans are not an exception and CR must increase both maximal and healthy lifespan in humans to the same degree as it does in other mammals. Unlike mice, however, humans benefit from medical care, which prolongs lifespan despite accelerated aging in non-restricted individuals. Therefore in humans the effect of CR may be somewhat blunted. Still how much does CR extend human lifespan? And could this extension be surpassed by gerosuppressants such as rapamycin?

PMID: 20139716

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