Calorie Restriction Weight Loss Avoids High Metabolic Rate, which Equals Death

Go on to Google and search on increasing metabolism weight loss. You’ll get more than six million hits. And just think about it: How many diet plans and weight-loss products claim to help you lose weight by increasing metabolic rate? Even some misguided calorie restriction diet plans recommend increasing metabolic rate.

They forgot to say that you may also lose your life. A new study from The Journal of Clinical Endocrinology & Metabolism confirms what CR Way travelers already intuitively know: A higher resting metabolic rate is associated with early mortality. In fact, for each 100-kilocalorie (the calories that we count) increase in energy expenditure per 24 hours, the likelihood of natural mortality increased by 1.29 percent.

Higher energy expenditure in humans predicts natural mortality.

Journal of Clinical Endocrinology and Metabolism. 2011 Jun;96(6):E972-6. Epub 2011 Mar 30.

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, Krakoff J.

MD, National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases, Department of Health and Human Services, 4212 North 16th Street, Phoenix, Arizona 85016.

Context: Higher metabolic rates increase free radical formation, which may accelerate aging and lead to early mortality.

Objective: Our objective was to determine whether higher metabolic rates measured by two different methods predict early natural mortality in humans.

Design: Nondiabetic healthy Pima Indian volunteers (n = 652) were admitted to an inpatient unit for approximately 7 days as part of a longitudinal study of obesity and diabetes risk factors. Vital status of study participants was determined through December 31, 2006.

•         Twenty-four-hour energy expenditure (24EE) was measured in 508 individuals,

•         resting metabolic rate (RMR) was measured in 384 individuals,

•         and 240 underwent both measurements on separate days.

Data for 24EE were collected in a respiratory chamber between 1985 and 2006 with a mean follow-up time of 11.1 (standard deviation, 6.5) yr and for RMR using an open-circuit respiratory hood system between 1982 and 2006 with a mean follow-up time of 15.4 (sd, 6.3) yr. Cox regression models were used to test the effect of EE on natural mortality, controlled for age, sex, and body weight.

Results: In both groups, 27 natural deaths occurred during the study period. For each 100-kcal/24 h increase in EE, the risk of natural mortality increased by 1.29 (95% confidence interval = 1.00-1.66; P < 0.05) in the 24EE group and by 1.25 (95% confidence interval = 1.01-1.55; P < 0.05) in the RMR group, after adjustment for age, sex, and body weight in proportional hazard analyses.

Conclusions Higher metabolic rates as reflected by 24EE or RMR predict early natural mortality, indicating that higher energy turnover may accelerate aging in humans.

PMID:21450984 – lightly edited from National Institutes of Health, National Library of Medicine, PubMed access to citations to biomedical literature in MEDLINE.

Meanwhile, the Washington University team did superb work on our CR cohort, showing that T3, an indicator of metabolic rate, is lowered by calorie restriction, as is seen in animal studies.*

*Fontana, L, Klein S, Holloszy J.O., Premachandra B.N. Effect of Long term Calorie Restriction with Adequate Protein and Micronutrients on Thyroid Hormones. Journal of Clinical Endocrinology & Metabolish 2006; 91:3232-3235.


A Healthful Calorie Restriction Diet

So is someone who needs to lose weight doomed to failure by the CR Way’s metabolic rate-lowering lifestyle?

Hardly. The combination of low calorie intake plus low glucose levels forces the body into a fat-burning mode as described in this blog post.

What you are really doing by following a calorie restriction dietwith this lifestyle is allowing your ancient defense system, which was developed when living organisms needed to go for long periods without food – to protect them.

•         Cell signals block fat-forming genes – providing you with energy from fat stores.

•         Pounds melt away not because you are increasing resting metabolic rate, but because fewer calories are available (not less food) in the first place,  and

•         Those that are available, keep glucose levels low – another important characteristic of a healthful weight loss diet.


For more see

The CR Way to Healthful Weight Loss


CR Way to Calorie Restriction, a healthy way to lose weight


What do our members say?

Just want to tell you both that with your help, encouragement, CR Way NutriBase and, most importantly, your example, I almost painlessly shed about one pound per week over the last 23 weeks. I look forward to my upcoming physical!


Most sincerely,

Mike Bell, Kenosha, WI

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